Bioactive Small Molecules
Cayman Chemical trns-Resveratrol 250mg
A polyphenol with diverse biological activities; inhibits the cyclooxygenase and hydroperoxidase activities of COX-1 (EC50s = 15 and 3.7 μM, respectively); inhibits ERK1, JNK1, Src, PKCα, aromatase/CYP19, and DNA polymerases α and δ (IC50s = 37, 50, 20, in vitro and/or ex vivo; exhibits anticancer, anti-inflammatory, and antiviral activities in mice
AdipoGen Splitomicin (5 mg)
Chemical. CAS: 5690-03-9. Formula: C13H10O2. MW: 198.2. Potent cell permeable and selective inhibitor of yeast NAD+-dependent histone deacetylase (HDAC) Sir2p. Displays higher activity in vivo than in vitro. Sensitizes mammalian cells to a variety of DNA-damaging agents by abrogating Sir2p activity on p53. Acts by either altering or blocking access to the acetylated histone binding pocket. Shown to have diverse effects also in mammalian cells.
AdipoGen Bisindolylmaleimide II (1 mg)
Chemical. CAS: 137592-45-1. Formula: C27H26N4O2. MW: 438.5. Protein kinase C (PKC) inhibitor. Binds with reversed orientation to protein kinase A (PKA).
AdipoGen Palitantin (1 mg)
Chemical. CAS: 15265-28-8. Formula: C14H22O4. MW: 254.3. Isolated from Penicillium sp. Antiprotozoal (Leishmania). Antifungal.
AdipoGen Altenusin (5 mg)
Chemical. CAS: 31186-12-6. Formula: C15H14O6. MW: 290.3. Isolated from Penicillium sp. Antibiotic. Antifungal penicillide. Non-competitive, specific neutral sphingomyelinase (N-SMase) inhibitor. Strong pp60c-Src inhibitor. Inhibits cFMS receptor tyrosine kinase (CSF-1/m-CSF receptor tyrosine kinase) which is implicated in cancer and bone diseases. Myosin light chain kinase inhibitor. Exhibits anti-HIV-1 integrase activity. Cytotoxic activity against mouse lymphoma cells. Anti-protozoan, trypanothione reductase (TR) inhibitor. Phytotoxin.
AdipoGen Ferutinin (high purity) (10 mg)
Chemical. CAS: 41743-44-6. Formula: C22H30O4. MW: 358.5. Semisynthetic. Potent, naturally occuring non-steroid estrogenic compound. Tool to promote mitochondrial calcium overload and to promote calcium-dependent opening of the mitochondrial permeability transition pore (mPTP). Strong agonist for estrogen receptor (ER)alpha and agonist/antagonist for ERbeta. Calcium ionophoretic Apoptosis modulator. Antiproliferative. Increases nitric oxide synthase activity and phosphoinositides breakdown in nervous tissue. Shows aphrodisiac and anti-sexual impotence activities. Anti-osteoporotic. Prevents osteoporosis caused by severe estrogen deficiency. Modest AChE inhibitor.
AdipoGen 3-O-Methylfluorescein
Chemical. CAS 70672-05-8. Formula C21H14O5. MW 346.33. Synthetic Used in fluorimetric studies. Fluorescent probe. Selective fluorometric substrate for CYP2C19 and CYP1A1. Reaction product of the substrate 3-O-methylfluorescein phosphate OMFP is hydrolyzed by phosphatases to yield O-methylfluorescein OMF that is detected at a 485nm excitation/525nm emission.
AdipoGen 7-Methoxy-4-methylcoumarin
Chemical. CAS 2555-28-4. Formula C11H10O3. MW 190.2. Synthetic. Coumarin derivative. Fluorescent label. Shown to be UVA-phototoxic against F. cultnorum and to have some weak biological activities.
AdipoGen HPTS
Chemical. CAS 6358-69-627928-00-3 free acid. Formula C16H7Na3O10S3. MW 524.39. Synthetic. Useful for optical sensor applications. Fluorescent pH indicator for physiological range.
AdipoGen ASPT
Chemical. CAS 159721-38-7. Formula C42H43BN2O. MW 602.61. Synthetic. Aminostyrylpyridinium hemicyanine dye with solvent-dependent one- and two-photon emission1.
AdipoGen 6-TET dipivaloate
Chemical. CAS 314734-87-7. Formula C31H24Cl4O9. MW 751.2274. Synthetic. 6-TET is an amino-conjugatable fluorescent probe that is widely used in nucleic acid sequencing and related research. It can also be used to label peptides and oligonucleotides.
AdipoGen DCIA
Chemical. CAS 76877-34-4. Formula C22H23IN2O3. MW 490.33. Synthetic. A label that can be used for preparing maleimide and iodoacetamide derivatives of 3-phenylcoumarin fluorophore. These derivatives can be self-quenching until they react with thiol groups and regain their strong fluorescence.
AdipoGen Roquefortine C
Chemical. CAS 58735-64-1. Formula C22H23N5O2. MW 389.5. Isolated from Penicillium sp. Potent neurotoxin. Mycotoxin. Tremorgenic. Gram-positive bacteria growth inhibitor. Cytochrome p450 inhibitor. Lymphocyte proliferation inhibitor. Cytotoxic.
Enzo Life Sciences Terbinafine HCl (100mg). CAS: 78628-80-5
Inhibits ergosterol biosynthesis at the level of squalene epoxidase. Potent non-competitive inhibitor of squalene epoxidase from Candida (Ki=30 nM), inhibiting mammalian enzymes at higher concentrations (4-77 µM). It inhibits HUVEC proliferation and angiogenesis and displays interesting anti-inflammatory and free radical scavenging activities. Clinically useful antifungal agent. Alternative name: trans-N-(6,6-Dimethyl-2-hepten-4-ynyl)-N-methyl-1-naphthylmethylamine . hydrochloride. Purity: ≥98% (UHPLC). Solubility: Soluble in ethanol (45 mg/ml), DMSO (30 mg/ml) or water (3 mg/ml). Long Term Storage: Ambient.
AdipoGen Lucigenin
Chemical. CAS 2315-97-1. Formula C28H22N4O6. MW 510.5. Synthetic. Chemiluminescent probe for the detection of peroxides in biological systems. Reagent used for the generation of chemiluminescence in the presence of a reductant and oxygen It is employed in numerous chemiluminescent assays. Lucigenin is specific for superoxide anion radical.